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st: handling zero random effects automatically in xtmixed
.
This is related to my previous post on xtmixed syntax. In a microarray
data set of gene expression, we are exploring parametric mixed model
gene set enrichment analysis (GSEA). SAS Proc Mixed seems to bully its
way through models with random effects that are essentially zero.
Stata doesn't converge. The solution is to troubleshoot the model,
maybe using emonly and 500 iterations, to verify a zero random effect,
remove it, reformulate the model and run it again. The problem is that
we are talking hundreds if not thousands of variance components mixed
models. There needs to be an automatic method of dealing with zero
estimated random effects. I don't know yet what SAS is doing
differently, but I will find out.
-Dave
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