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From | Michael McCulloch <mm@pinestreetfoundation.org> |
To | Statalist Statalist <statalist@hsphsun2.harvard.edu> |
Subject | st: pk analysis suite: elementary questions about -pkequiv-, -pkcross-, and -pkshape- |
Date | Fri, 19 Feb 2010 17:00:30 -0800 |
Hello Statalist friends, I'm studying the manual (v11) for the pk suite, and have 3 questions:1. Regarding the "carry" variable created by -pkshape-, in the manual example (p. 1325), is "carry" simply an indicator that shows whether or not a measurement was made in the same period/treatment combination, so that if
"carry"==0, then no carryover is possible, and if "carry"==A, then a carryover effect is possible, but no evidence yet?2. Can -pkcross- be used in to compare treatment response (e.g. pain score) in an AB-BA crossover study design, that was not a test of a biopharmaceutical drug concentration?
3. -pkequiv- performs bioequivalence tests using serum levels of biopharmaceutical drug concentration. Can the command also be used instead to measure *any* continuous outcome, measured following some other non-pharmaceutical intervention?
Best wishes, Michael McCulloch Pine Street Foundation 124 Pine Street San Anselmo, CA 94960-2674 tel: 415-407-1357 fax: 206-338-2391 * * For searches and help try: * http://www.stata.com/help.cgi?search * http://www.stata.com/support/statalist/faq * http://www.ats.ucla.edu/stat/stata/