David Airey wrote:
I was looking at the following citation, and found the author
explicitly argued against using Stata for a particular 2x2 exact test.
[snip]
[Quote from article:] (ii) Comparative trials (singly conditioned).
These correspond to the usual experimental design in biomedical
work, in
which a sample of convenience is randomized into two treatment
groups, so
that the group (column) totals are fixed in advance. The proper
tests of
significance are exact tests on the odds ratio, on the ratio of
proportions
(relative risk and risk ratio) or on the difference between
proportions.
[snip] . . . for an exact test on OR=1,
it is safe only to use the Testimate single-conditioned
option. For the exact test on RR=1, and for the exact
test on the difference in proportions (p2 - p1=0), it is
safe to use StatXact and Testimate, but not Stata.
--------------------------------------------------------------------------------
David,
Did Prof. Ludbrook (or anybody) indicate what algorithms Testimate
6.0 uses
for exact tests of odds ratio = 1, relative risk = 1 and risk
difference = 0
in the randomized clincial trial (single-conditioned) situation?
Joseph Coveney
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