st: Area under the curve

[Peter DeGaris <pdegaris@bigpond.com>]

Hi All,

I am currently using Stata 9.2 July 2007.

I have a rather unusual pharmacokinetic type data set that I need to run 
AUC's on.  The time axis is both positive and negative and hence the two 
sections of the data need to be analysed separately (day -35 to day 0 
and day 0 to day +35).  The follow up times are not identical for 
patients either before or after day 0 (ie different time points for the 
data for different patients). Some patients have a missing value at time 
= 0.

I have split the data set to allow calculation of the AUC for the 
negative time period by making these negative times positive.

I want to fit a cubic spline to the data and then calculate the AUC for 
varying time periods (ie day - 10 to day 0 or day 0 to day +10).  I have 
been trying to do this using the pkcollapse function.
Due to the irregular follow up times for different patients and some 
missing data at time=0, I need Stata to fit the spline and calculate the 
AUC under the spline for each patient for a consistent period say (day 0 
to day +10) even if that particular patient has only data points at say 
day 0, 1, 4, 8, 12, 16 .  ie day 10 data value would need to be 
predicted from the cubic spline to have the AUC calculated over day 0 to 
10  and not the AUC from day 0 to 8.  In addition I don't want Stata to 
insert a value of 0 at time=0 if that measurement is missing.
I hope that's a clear enough explanation???

Cheers

Peter DeGaris
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