st: Multiple (about 100 to 150) repeated measurements in 68 allergic individuals: association with daily measured pollutants

["George Konstantinou" <georgenk@med.auth.gr>]

Dear Statalist,



I have a datasheet which are consisted of 68 individuals well diagnosed as 
allergic to three specific aeroallergens. For each individual there are 100 
to 150 daily scores (repeated measurements) during a 6 month period of time. 
Each score (0=no symptoms to 5=severe symptoms, continuous variable) comes 
from a specific questionnaire each patient was supposed to fill in and 
corresponds to the severity of the symptoms (subjective: respiratory 
symptoms such as asthma symptoms, cough, wheeziness, catarrh etc, scored 
every day from the patient; objective: every day peak expiratory flow rate 
measurement). The measurements are NOT from the same day for all 
individuals. For all these 6 months I have recorded the aeroallergens' and 
pollutants' load in the atmosphere, the temperature and the humidity 
(continuous variables).

1)     I would like to figure out if there is an association between the 
severity of the symptoms with all the continuous variables and

2)     Also to do the same with the exacerbations of asthma symptoms (binary 
outcome: having an exacerbation or not having which is also defined from the 
aforementioned scores) with the same continuous variables.

3)     The second thing has to do with the logical thought that perhaps the 
symptoms are getting more severe after some days of e.g. heavy loads of 
pollutants and not necessarily the same day. So how can I check if there is 
such a pattern?

Which you think is the appropriate statistical approach to deal with these 
data and how can I apply that approach to Stata?

My name is George Konstantinou and I am a second-year postgraduate student 
in biostatistics in the School of Medicine of the National and Kapodistrian 
University of Athens. This is the dissertation I have to write and present 
to get my Master's degree.

I would like to thank you all in advanced for your time and your help and I 
am looking forward for your advice!







Best regards,





George Konstantinou, MD
Sapfous Str, 70
Nea Lesvos
Amarousion 151 26
Athens, Greece
Tel: +30 210 8105858
Mobile: +306977281002
email: georgenk@med.auth.gr





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