Dear all,
Please pardon the non-Stata topic.
We recently submitted a manuscript for publication to
a major medical journal. It was a case-control study
with 329 cases and 126 controls. One of the reviewers
wrote that "to have such a larger number of cases was
statistically atypical" and asked if the "authors find
that the use of the same control for multiple patients
significantly limits results"?
I never heard of any biases or other problems cause by
having more cases than controls in a study. We had
sufficient power and the difference for our main
outcome was highly significant (less than 0.00001). Am
I missing something or is it that this reviewer does
not understand the case-control designed? By the way
this was not a matched study design.
Thank you,
Ricardo.
__________________________________
Do you Yahoo!?
Yahoo! Finance Tax Center - File online. File on time.
http://taxes.yahoo.com/filing.html
*
* For searches and help try:
* http://www.stata.com/support/faqs/res/findit.html
* http://www.stata.com/support/statalist/faq
* http://www.ats.ucla.edu/stat/stata/
